Meeting Banner
Abstract #2349

Voxel-based morphometry for evaluating nigrostriatal damage in unilateral 6-OHDA-induced Parkinson’s rat model

Sadhana Kumari1, S Senthil Kumaran1, Bharti Rana2, Shefali Chaudhary3, and Suman Jain4
1Department of NMR, All India Institute of Medical Sciences, New Delhi, India, 2Department of Computer Science, University of Delhi, Delhi, India, 3Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States, 4Department of Physiology, All India Institute of Medical Sciences, New Delhi, India

Synopsis

Keywords: Parkinson's Disease, Segmentation

Motivation: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra pars compacta resulting in classical motor and nonmotor symptoms.

Goal(s): Our goal was to characterise the gray matter atrophy in 6-OHDA PD model as compared to sham control.

Approach: Structural MRI (3D T1W images) combined with behavioural techniques was used.

Results: Voxel based morphometry (VBM) revealed reductions of gray matter volume in Fimbria (Ipsi), hippocampal formation (Ipsi) and accumbens nucleus (contra) in 3rd week PD and cerebellum (Ipsi and contra both) in 7th week PD as compared to sham.

Impact: Identification of gray matter atrophy longitudinally helps in understanding the progression of structural alterations in response to dopaminergic cell loss.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords

weekshamgray