Abstract #2354

Structural connectivity networks of putamen subregions in health and in early Parkinson’s Disease

Tonima Sumya Ali^1,2, Jinglei Lv^1,2, Arkiev D'Souza^1,2,3, Claire O'Callaghan^2,4, Marshall Dalton^2,5, Mustafa Steve Kassem⁶, and Fernando Calamante^1,2,7

¹School of Biomedical Engineering, The University of Sydney, Sydney, Australia, ²Brain and Mind Centre, The University of Sydney, Sydney, Australia, ³National Imaging Facility, Sydney, Australia, ⁴School of Medical Science, The University of Sydney, Sydney, Australia, ⁵School of Psychology, The University of Sydney, Sydney, Australia, ⁶Neuroscience Research Australia, Sydney, Australia, ⁷Sydney Imaging, The University of Sydney, Sydney, Australia

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Brain connectivity, Diffusion MRI

Motivation: Putamen, a subcortical grey matter (SGM) structure and its associated brain connectivity networks are often implicated in the early stages of Parkinson’s Disease (PD).

Goal(s): With more detailed structural connectivity analysis using SGM parcellation, we characterise the structural connectivity of putamen subregions in healthy brains, and their alterations in early PD.

Approach: Using data from Parkinson’s Progressive Markers Initiative, structural connectivity analysis, and by incorporating SGM parcellation, we have revealed the connectivity networks specific to four putamen subregions.

Results: Heterogeneous connectivity alteration was identified in PD subjects, demonstrating weakening of intra-SGM connectivity within hemisphere and strengthening of it across hemispheres.

Impact: We identified structural connectivity networks specific to four putamen subregions in healthy brain and in early Parkinson’s Disease. Our method allows focused connectivity analysis while our findings provide new insight into the intra- and inter-hemispheric connectivity alterations with disease progression.

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