Meeting Banner
Abstract #2368

Quantitative susceptibility mapping in the newborn brain with source separation: Comparison of preterm and full-term infants

MinJung Jang1, Alexey V. Dimov1, Shin-Eui Park1, Eric J. Mallack2, Yi Wang1, Thanh D. Nguyen1, and Zungho Zun1
1Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 2Department of Pediatrics, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Neonatal, Quantitative Susceptibility mapping

Motivation: Estimating iron and myelin contents in the newborn brain can be used to access neurodevelopment, but is challenging with conventional quantitative susceptibility mapping.

Goal(s): To separate positive and negative susceptibilities in the newborn brain and investigate differences between preterm and full-term newborns.

Approach: A total of 22 full-term and 10 preterm newborns were studied using quantitative susceptibility mapping with R2*-based source separation. Mean susceptibilities within 10 regions-of-interests were compared between full-term and preterm newborns.

Results: Preterm brains showed less positive and negative susceptibilities, compared to the full-term brains.

Impact: This study suggests that positive and negative magnetic susceptibilities in the newborn brain may be estimated individually using quantitative susceptibility mapping with source separation and may be used to identify early deviations from normal neurodevelopment in preterm-born infants.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords

susceptibilityterm