Keywords: Neuro, Pediatric, Other Interventional
Motivation: Infantile Tremor syndrome (ITS) is a neurocutaneous syndrome observed in infants breastfed by vegetarian mothers who are deficient in vitamin B12. Its is accompanied by cerebral and white matter atrophy, delayed myelination, and delayed neurodevelopment.
Goal(s): To evaluate the efficacy of B12 treatment in infants with ITS on microstructural development and myelination using DTI.
Approach: In this longitudinal study, changes in DTI metrics are evaluated before and after vitamin B12 treatment using an atlas-based approach.
Results: Results show substantial increases in WM FA and decrease in WM RD, as evidence of the role of B12 in the myelination process.
Impact: Our findings will contribute to understanding the pathophysiological basis of ITS and highlight the efficacy of B12 treatment in rapidly reversing delayed brain development
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