Abstract #2387

Assessment of individualised cortical gyrification in infants with congenital heart disease

Daniel Cromb¹, Siân J Wilson¹, Alexandra Bonthrone¹, Andrew Chew¹, Christopher Kelly¹, Manu Kumar², Paul Cawley¹, Ralica Dimitrova¹, Kuberan Pushparajah³, John Simpson³, Mary Rutherford¹, David Edwards¹, Joseph V Hajnal¹, Jonathan O'Muircheartaigh¹, and Serena J Counsell¹

¹Centre for the Developing Brain, King's College London, London, United Kingdom, ²GKT Medical School, King's College London, London, United Kingdom, ³Department of Cardiovascular Imaging, School of Biomedical Engineering & Imaging Science, King's College London, London, United Kingdom

Synopsis

Keywords: Neuro, Pediatric, Cortex

Motivation: Congenital heart disease (CHD) is common and associated with impaired early brain development.

Goal(s): To assess whether preoperative cortical Gyrification Index (GI) in infants with CHD deviates from the normal trajectory.

Approach: GI trajectories were normatively-modelled using reference control MRI data from 320 healthy infants, enabling calculation of GI Z-scores for the whole brain and frontal, occipital, parietal, temporal, cingulate and insular cortices for 130 infants with CHD, after accounting for sex, postmenstrual age at scan and days since birth at scan.

Results: Mean GI Z-scores were significantly lower for the whole brain and all cortical regions in infants with CHD (All P_FDR<0.018)

Impact: Global and regional brain gyrification is reduced in infants with critical or severe CHD in the neonatal period, prior to cardiac surgery, and these individualised measures of cortical folding are significantly associated with cerebral oxygen delivery in the neonatal period.

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