Keywords: Tumors (Pre-Treatment), Cancer, metabolism, spectroscopy
Motivation: Metabolic mapping in Diffuse intrinsic pontine glioma (DIPG) may indicate prognosis and potential therapeutic targets.
Goal(s): We intended to identify metabolic ratios that indicated dysregulated metabolic pathways using 1H-MRS and determine whether these metabolites are associated with overall survival length.
Approach: We performed CSI in patients with DIPG prior to radiation therapy. Then we assessed the predictive value of a metabolite ratio for patient overall survival.
Results: Lactate and total choline levels were found to be significantly associated with patient overall survival, making them potential prognostic predictors of overall survival in DIPG.
Impact: This study shows that more aggressive DIPGs are metabolically distinct from less aggressive tumors and that the metabolic differences can predict the overall survival of patients.
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