Abstract #2399

Differentiating Low- and High-Grade Pediatric Brain Tumor Using Integrated DWI

Albert Yen^1,2, Muge Karaman^1,3, Guangyu Dan^1,3, He Wang⁴, Yuhua Li⁵, and Xiaohong Joe Zhou^1,3,6

¹Center for Magnetic Resonance Research, University of Illinois Chicago, Chicago, IL, United States, ²Medical Scientist Training Program, University of Illinois Chicago, Chicago, IL, United States, ³Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL, United States, ⁴Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ⁵Department of Radiology, Xin Hua Hospital, Shanghai, China, ⁶Department of Radiology and Neurosurgery, University of Illinois Chicago, Chicago, IL, United States

Synopsis

Keywords: Cancer, Brain, pediatric brain tumor

Motivation: Pediatric brain tumors is the most common cancer among the pediatric population, and DWI-imaging offers a non-invasive method to assess tumor grade to guide appropriate treatments.

Goal(s): The study investigates the feasibility of DISMANTLE, an integrated DWI approach for simultaneous assessment of tissue cellularity, vascularity, and heterogeneity, in differentiating high-grade and low-grade pediatric brain tumors.

Approach: Seventy pediatric patients with brain tumors, categorized into high-grade and low-grade, were scanned with DWI sequence. Images were analyzed using DISMANTLE and 3 comparison models.

Results: Removing the perfusion-related signal in DISMANTLE improved the accuracy and sensitivity of diffusion-related parameters in assessing pediatric brain tumor grades.

Impact: The study emphasizes the importance of appropriate signal characterization and fitting strategies for high b-value DWI in robust assessment of brain tumors. Future DWI modeling should consider segmentally fitting the diffusion and perfusion-related signals.

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