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Abstract #2423

Correcting temperature related diffusivity drift for postmortem diffusion MRI

Michael Paquette1, Cornelius Eichner1, Christian Bock2, and Alfred Anwander1
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany

Synopsis

Keywords: Diffusion Reconstruction, Diffusion/other diffusion imaging techniques, Postmortem

Motivation: In diffusion MRI, large post-mortem samples reach steady-state temperature and diffusivity only after a very long scan time.

Goal(s): Our goal was to use data during steady-state temperature adaptation to model changing diffusivity and still obtain reliable tissue orientations.

Approach: We estimated the diffusivities at steady-state temperature with a subset of the data and computed the temperature correction coefficients from the difference between predicted and measured data.

Results: The corrected data has greatly increased test-retest agreement and angular accuracy of fiber orientation estimates.

Impact: Accelerate post-mortem diffusion MRI by replacing dummy scans with our new data-driven temperature modeling.

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Keywords