Abstract #2431

Pushing the boundaries of in-vivo human diffusion MRI using Romer-EPTI: initial results on the Connectome 2.0 scanner

Zijing Dong^1,2, Timothy G. Reese^1,2, Hong-Hsi Lee^1,2, Yixin Ma^1,2, Gabriel Ramos Llordén^1,2, Daniel J. Park^1,2, Mirsad Mahmutovic³, Boris Keil³, Bruce R. Rosen^1,2,4, Jonathan R. Polimeni^1,2,4, Susie Y. Huang^1,2,4, Lawrence L. Wald^1,2,4, and Fuyixue Wang^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Science, Giessen, Germany, ⁴Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Diffusion Acquisition, Data Acquisition, Diffusion Acquisition

Motivation: The progress in in-vivo high-resolution and high-b-value dMRI has advanced the investigation of structural connectivity and tissue microstructure.

Goal(s): We aim to further push the spatial resolution and b-value of in-vivo diffusion MRI.

Approach: A high-SNR(√25x), distortion-free, motion-robust Romer-EPTI technique that addresses the challenges in dMRI acquisition with further enhanced capabilities by taking advantage of the cutting-edge Connectome 2.0 scanner.

Results: We demonstrate motion-robust distortion-free in-vivo mesoscale dMRI (~485um-istropic) on clinical 3T&7T scanners, and further improvements in SNR on Connectome2.0 scanner enabling high-SNR, high b-value dMRI and a spatial resolution up to 400um-iso.

Impact: Romer-EPTI achieves high-SNR motion-robust distortion-free in-vivo mesoscale dMRI (~485 um) with exceptional quality on clinical 3T&7T scanners. Its capabilities were further enhanced on the Connectome 2.0 scanner, enabling high-SNR high b-value dMRI and a spatial resolution up to 400um-iso.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.