Abstract #2435

Comparison of time-division multiplexing and multi-echo sequences for accelerated relaxation diffusion MRI

Qiang Liu^1,2, Ante Zhu³, Imam Ahmed Shaik¹, Maxim Zaitsev⁴, Thomas Foo³, Jon-Fredrik Nielsen⁵, Carl-Fredrik Westin¹, Yogesh Rathi¹, and Lipeng Ning¹

¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ²School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ³Technology and Innovation Center, GE Healthcare, Niskayuna, NY, United States, ⁴Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ⁵fMRI Laboratory and Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: Diffusion Acquisition, Quantitative Imaging

Motivation: Compare multi-echo and time-division multiplexing (TDM) sequences that accelerate multi-TE dMRI scans.

Goal(s): To investigate the accuracy of multi-TE diffusion measures using multi-echo and TDM sequences.

Approach: Standard single-TE spin-echo echo-planar imaging (EPI), dual-echo EPI, and TDM-EPI sequences were implemented using Pulseq with matched diffusion and readout gradients. A calibration phantom and a human subject were scanned on two scanners to examine the accuracy of R2 (1/T2) and apparent diffusivity coefficient (ADC) maps.

Results: TDM demonstrates up to 160% reduction in estimated R2 on phantom and 30% in in-vivo data compared to dual-echo sequence.

Impact: The proposed TDM sequence allows for fast and accurate T2 and ADC estimation compared to the conventional multi-echo sequence, making it a potential tool for relaxation-diffusion imaging.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.