Abstract #2442

Three-dimensional phase-based diffusion imaging using RF phase-modulated gradient echo imaging with Stack-of-Stars

Daiki Tamada¹, Diego Hernando^1,2, and Scott B Reeder^1,2,3,4,5

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Emergency, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Diffusion Acquisition, Diffusion/other diffusion imaging techniques

Motivation: There is increased interest in high-resolution diffusion-weighted imaging (DWI); however, conventional DWI methods have limitations such as image distortion and motion sensitivity.

Goal(s): To demonstrate the feasibility of high-resolution DWI using phase-based diffusion with radial Stack-of-Stars acquisition (PBD-SoS).

Approach: To evaluate PBD-SoS, quantitative ADC measurements were performed with a phantom and compared with conventional methods. In vivo imaging was performed to demonstrate the clinical feasibility of PBD-SoS.

Results: The results showed ADC values of the phantom measured using PBD-SoS were consistent (R²=0.99) with conventional DWI, and there were fewer motion artifacts compared to conventional methods in vivo.

Impact: PBD-SoS enables high-resolution DWI that is robust to motion, which can be particularly beneficial for body imaging where motion artifacts are common. While current PBD-SoS scans may take longer, future implementation of acceleration techniques could overcome this limitation.

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