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Abstract #2446

Submillimeter in vivo human brain diffusion MRI at 500 mT/m with concurrent field monitoring

Gabriel Ramos-Llordén1, Mirsad Mahmutovic2, Daniel J. Park1, Chiara Maffei1, Yixin Ma1, Hong-Hsi Lee1, Lawrence L. Wald1, Thomas Witzel3, Boris Keil2,4, and Susie Y. Huang1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Institute of Medical Physics and Radiation Protection, Mittelhessen University of Applied Sciences, Giessen, Germany, 3Q Bio Inc, San Carlos, CA, United States, 4Department of Diagnostic and Interventional Radiology, University Hospital Marburg, Philipps University of Marburg, Marburg, Germany

Synopsis

Keywords: Diffusion Acquisition, Data Acquisition

Motivation: High-fidelity, artifact-free diffusion MRI (dMRI) in high-performance gradient systems requires more advanced encoding and reconstruction approaches than those widely used.

Goal(s): To achieve ghosting- and eddy current distortion-free in vivo submillimeter human brain dMRI with concurrent field monitoring.

Approach: A 16-ch clip on field probe system was integrated onto custom-built 72ch to map high-order field perturbations during the acquisition. SENSE-based reconstruction was informed with the monitored phase evolution as expressed in a 3rd-order spherical harmonic model.

Results: Concurrent field monitoring reconstruction reduces non-linear Nyquist ghosting and geometric distortions generated by high-order eddy currents from ultra-strong diffusion gradients.

Impact: We expect concurrent field monitoring to become essential in achieving high-quality image reconstruction as the adoption of high-performance gradients systems grows and image acquisition strategies evolve with more sophisticated image encodings.

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Keywords