Abstract #2460

In-vivo high-resolution χ-separation (chi-separation) at 7T

Jiye Kim¹, Hyeong-Geol Shin^2,3, Minjun Kim¹, Sooyeon Ji¹, Kyeongseon Min¹, Hwihun Jeong¹, Seong-Gi Kim^4,5, and Jongho Lee¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, ⁵Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: Susceptibility/QSM, Susceptibility, High-resolution anatomy

Motivation: High-resolution χ-separation at 7T can delineate detailed structures related to iron and myelin concentrations in the brain. However, it has the challenge of requiring an R2 map, which is not practical at 7T due to SAR and scan time.

Goal(s): Our objective is to generate high-resolution χ-separation maps at 7T.

Approach: An R2* 7T-to-3T conversion network to transform a 7T R2* map into its 3T counterpart is developed. Then, 𝜒-separation is processed via QSMnet, χ-sepnet-R2*, and resolution generalization.

Results: We successfully produced high-quality and high-resolution 𝜒-separation maps only from multi-echo gradient echo data at 7T.

Impact: This study suggests a solution for the technical challenge of requiring R2 map in 7T χ-separation, enabling high-resolution (=650 um) χ-separation. This may benefit the analysis of iron and myelin concentration changes in various neurodegenerative diseases through detailed structural examination.

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