Abstract #2465

Visualization of iron and myelin cytoarchitecture in postmortem human brain using sub-millimeter multi-orientation chi- separation

Hyeong-Geol Shin^1,2, Yuto Uchida¹, Javier Redding-Ochoa³, Kengo Onda¹, Alexander Barrett³, Adnan Bibic², Juan C. Troncoso³, Peter van Zijl^1,2, Kenichi Oishi^1,4, and Xu Li^1,2

¹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴The Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease, Baltimore, MD, United States

Synopsis

Keywords: Susceptibility/QSM, Electromagnetic Tissue Properties

Motivation: While high-resolution quantitative susceptibility mapping (QSM) reveals unprecedented anatomical cytoarchitectures, delineation of certain substructures may be limited in regions containing both iron and myelin.

Goal(s): To demonstrate iron and myelin-specific anatomy inside human brain using sub-millimeter susceptibility source-separation (chi-separation).

Approach: Sub-millimeter multi-orientation QSM and chi-separation were obtained on postmortem human hemibrain at 7T. Capabilities of QSM, χ_para and χ_dia contrasts for delineating neuroanatomy were compared.

Results: While iron-rich substructures like line of Gennari can be readily identified in QSM, χ_dia helps reveal small fibers including striatal tracts, perforant pathway and fibers in cortical/subthalamic area.

Impact: Sub-millimeter susceptibility source separation images can delineate neuroanatomical substructures in the human brain with increasing specificity to iron or myelin related cytoarchitecture.

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