Keywords: Susceptibility/QSM, Quantitative Susceptibility mapping, Susceptibility source separation, R2* mapping, Artifact correction, Iron imaging, Myelin imaging
Motivation: An advanced quantitative susceptibility mapping (QSM) technique, χ-separation, requires tissue field map and R2* to separate paramagnetic and diamagnetic components. As the background field is removed to acquire the tissue field map, the background R2* needs to be removed to accurately estimate paramagnetic and diamagnetic susceptibility maps.
Goal(s): Investigate the effect of background R2* correction on χ-separation.
Approach: The effect of background R2* correction on χ-separation was tested by varying the background R2* with multiple head orientations and k-space filtering.
Results: Background R2* correction successfully reduced overestimation in χ-separation maps in different head orientations and low-pass filtering levels.
Impact: Background R2* correction enables consistent χ-separation across different head orientations and k-space filtering.
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