Keywords: Neurofluids, Data Analysis, Arachnoid granulation, sleep, cerebrospinal fluid
Motivation: The high prevalence of sleep dysfunction in Parkinson disease (PD) leads to chronic dysregulation of the CSF circuits.
Goal(s): Hypotheses regarding arachnoid granulation (AG) hypertrophy in patients with PD and its relationship to sleep dysfunction were tested.
Approach: Sleep quality was assessed in PD patients. Using high resolution MRI and a novel deep-learning method, we assessed volumetrics measures of AG in the superior sagittal sinus.
Results: We found that increased AG volumetrics in PD are significantly correlated with an increase of self-reported sleep disturbance and diurnal sleepiness, as well as actigraphy-based metrics of decreased sleep efficiency and increased wake after sleep onset.
Impact: Findings suggest that sleep dysfunction plays a role intravenous AG morphology. This motivates future structural and functional imaging analysis of AG to understand how increased AG volume impacts patients with neurodegenerative proteinopathy and how dysfunctional sleep influences this relationship.
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