Keywords: Neurofluids, Neurofluids, perivascular space, explained variance of CSF
Motivation: Estimating cerebrospinal fluid (CSF) in perivascular spaces (PVS) is essential to advance understanding of glymphatic clearance of cerebral waste products.
Goal(s): This study aimed to explore a novel method for evaluating CSF in PVS in awake subjects, including healthy controls and those with mild cognitive impairment (MCI).
Approach: We analyzed the explained variance of CSF components (CSF-derived R2) in resting-state fMRI images to determine the proportionate volume of PVS.
Results: We observed a decline in CSF-derived R2 with aging in healthy controls. Conversely, elevated CSF-derived R2 in MCI participants suggests enlargement of PVS, which may implicate altered glymphatic function in cognitive disorders.
Impact: The CSF-derived R2 metric from resting-state fMRI images offers a quantifiable assessment of CSF volume in perivascular spaces of the gray matter, holding potential as a biomarker for investigating glymphatic system efficiency.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords