Abstract #2472

Perivascular space semi-automated segmentation (PVSSAS) of 7T images from patients with and without epilepsy following traumatic brain injury

Jason A Reich¹, Krystyna Mylostna¹, Kristen Dams-O'Connor^2,3, Katherine Dorman², Guarav Verma⁴, Priti Balchandani⁴, Bradley Delman⁴, Madeline Fields³, Ji Yeoun Yoo³, Lara Marcuse³, Erin L MacMillan⁵, and Rebecca E Feldman^1,6

¹Department of Computer Science, Mathematics, Physics and Statistics, University of British Columbia, Kelowna, BC, Canada, ²Department of Rehabilitation and Human Performance, Brain Injury Research Centre, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵UBC MRI Research, Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Traumatic Brain Injury, Epilepsy

Motivation: Perivascular spaces (PVSs) are small fluid-filled spaces between blood vessels and pia mater. PVSs may appear differently in traumatic brain injury (TBI) patients with and without post-traumatic epilepsy (PTE) due to their role in waste removal.

Goal(s): To investigate characteristics of PVSs in PTE relative to TBI without PTE and healthy controls.

Approach: A semi-automated workflow for segmenting PVSs was established and applied to images from a 7T MRI study, including 8 TBI patients with PTE, 18 TBI patients without PTE, and 22 healthy controls.

Results: Larger median PVS equivalent diameter was observed in TBI, particularly with PTE, suggesting enlarged PVSs in TBI.

Impact: Identification of increased median perivascular space equivalent diameter in traumatic brain injury, particularly cases that develop post-traumatic epilepsy as shown in this work, may improve diagnosis and prognostication for post-traumatic epilepsy.

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