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Abstract #2499

Evaluating Obstructive Sleep Apnea Neuropathophysiology with 1H-MRS and Cerebral Small Vessel Disease Imaging

Christopher Bull1,2, Tairon Zhang1,2, Kurt Lancaster3, Peter Burke1,4, Mark Butlin4, Corey Botansky1, Katharina Schregel5, Arunan Srirengan1,2, Ruth Peters2,6, Caroline Rae1,2, Lucette Cysique2,7, Elizabeth Brown1,8, Lynne Bilston1,2, and Lauriane Jugé1,2,9
1Neuroscience Research Australia, Sydney, Australia, 2University of New South Wales, Sydney, Australia, 3St Vincent Applied Medical Research Centre, Sydney, Australia, 4Department of Biomedical Sciences, Macquarie University, Sydney, Australia, 5Heidelberg University Hospital, Heidelberg, Germany, 6The George Institute, Sydney, Australia, 7Kirby Institute, Sydney, Australia, 8Prince of Wales Hospital, Sydney, Australia, 9UNSW Ageing Futures Institute, Sydney, Australia

Synopsis

Keywords: Neuroinflammation, Spectroscopy, Obstructive sleep apnoea, cerebral small vessel disease

Motivation: 1H-MRS may be sensitive enough to detect neuropathological mechanisms of cerebral small vessel disease in obstructive sleep apnoea (OSA).

Goal(s): To investigate the relationships between nocturnal blood pressure surges (caused by sleep disturbances) and hypoxic burden (due to recurring apnoeas) on 1H-MRS metabolite levels and cognitive performance.

Approach: Seven controls and 23 participants with OSA underwent brain MRI, sleep physiological assessment and neuropsychological battery.

Results: A higher hypoxic burden was associated with higher cellular energy (Cr/H2O) and acute inflammation (GPC/H20), while more frequent blood pressure surges were associated with higher chronic neuroinflammation (mI/H20). There were no associations with cognitive performance.

Impact: Estimates of 1H-MRS metabolite levels, along with CSVD standard neuroimaging assessment, provide additional information concerning the neuro-cardiovascular and hypoxic burden associated with OSA that could potentially translate into improved early CSVD diagnosis in high-risk populations due to OSA.

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Abstract

Keywords