Keywords: Neuroinflammation, Multiple Sclerosis, Ex vivo; Ultra-high-resolution; Postmortem
Motivation: Cortical lesions in multiple sclerosis are clinically relevant but cannot be detected reliably using conventional MRI. Ex vivo ultra-high-resolution MRI is reliable in cortical lesion detection.
Goal(s): Identify cortical lesions on ex vivo 7T MRI in comparison to postmortem in situ conventional 3T MRI.
Approach: Retrospective visual assessment of cortical lesions on conventional MRI.
Results: 3T T1-weighted MPRAGE showed the highest sensitivity (66%), followed by T2-weighted SPACE (52%), and 3D FLAIR (48%) for detection of cortical lesions. Purely cortical lesions were less visible on in situ MRIs. Some leukocortical lesions appeared juxtacortical white matter lesions on conventional MRI.
Impact: Ultra-high-resolution MRI provides a platform to investigate substrates of cortical pathology in multiple sclerosis by bridging the gap between macroscopic conventional MRI and pathology.
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