Abstract #2504

Linking inter-individual differences in brain structure to post-COVID fatigue

Wenrui Bao¹, Xuan Niu², Zhaoyao Luo², Huijie Yuan², Tao Lu², Weixian Bai³, Junya Mu², Xiaocheng Wei⁴, and Ming Zhang²

¹School of Future Technology, Xi’an Jiaotong University, Xi'an, China, ²Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China, ³Department of Medical Imaging, The Affiliated Hospital of Northwest University·Xi’an No.3 Hospital, Xi'an, China, ⁴GE HealthCare MR Research, Beijing, China, Beijing, China

Synopsis

Keywords: Neuroinflammation, COVID-19

Motivation: Identify individuals at risk of developing post-COVID fatigue

Goal(s): Propose a "vulnerability" hypothesis of post-COVID fatigue

Approach: A multi-center, prospective, longitudinal study

Results: The GMV in frontal-limbic regions may serve as potential neural underpinnings that identify individuals at risk of developing post-COVID fatigue

Impact: Our findings emphasized the essential role of frontal-limbic system in the development of post-COVID fatigue, which will improve public health interventions by allowing for the early identification of individuals at risk of persistent post-COVID fatigue and facilitating subsequent neuromodulation treatment.

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