Keywords: Multiple Sclerosis, Multiple Sclerosis
Motivation: The enlarged choroid plexus (CP) in relapsing-remitting multiple sclerosis (RRMS) patients may further cause glymphatic function change and brain tissue damage.
Goal(s): To explore potential links between structural brain changes in RRMS patients and CP volume as well as glymphatic function.
Approach: Brain structural volume was obtained by Freesurfer segmentation. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used to assess the function of glymphatic system.
Results: In both cross-sectional and longitudinal studies, RRMS patients had increased CP volume and decreased DTI-ALPS index. Impaired glymphatic clearance partially mediates the effects of CP enlargement on brain structural changes.
Impact: Enlarged CP and impaired glymphatic system in RRMS patient may cause brain tissue damage. Using CP as a target for interventions may be beneficial to improve glymphatic system function and become a promising treatment strategy.
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