Keywords: Neuro, Diffusion/other diffusion imaging techniques, OGSE; IMPULSED; Glioblastoma; cellularity；cell diameter
Motivation: Gliomas are the most common type of central nervous system tumors in children, and the histological classification plays a crucial role in determining the prognosis and the treatment. A non-invasive approach is needed for pre-surgery characterization of the histopathology of the tumor.
Goal(s): The aim of this study was to explore the feasibility of applying time-dependent diffusion magnetic resonance imaging (td-dMRI) parameters in discriminating between high-grade gliomas (HGG) and low-grade gliomas (LGG).
Approach: Nine pediatric glioma patients were involved and underwent td-dMRI scan.
Results: The td-dMRI parameters may serve as potential markers for the differentiation between high-grade gliomas (HGG) and low-grade gliomas (LGG).
Impact: Time-dependent diffusion MRI parameters can distinguish pediatric high-grade and low-grade gliomas noninvasively, aiding personalized treatment and enhancing prognosis, among other potential applications.
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