Abstract #2552

Altered Functional Connectivity in the Brain Induced by Early-life Mild Necrotizing Enterocolitis

Ying-wei Sung¹, Chih-Hao Yang², Bao-Yu Hsieh^3,4, Chao-Ching Huang⁵, Chia-Feng Lu¹, and Yu-Chieh Jill Kao¹

¹Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²Department of Pharmacology, Tapei Medical University, Taipei, Taiwan, ³Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ⁴Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ⁵Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Synopsis

Keywords: Neuro, Preclinical

Motivation: According to the clinical findings, the survivors of necrotizing enterocolitis (NEC) may suffer from long-term neurodevelopmental impairment. However, how the local intestine inflammation impacts brain function needs further investigation.

Goal(s): To probe the long-term alteration in the brain network induced by NEC in early life.

Approach: After employing a neonatal rat model of NEC with lipopolysaccharide at postnatal 7 days, we measured the functional connectivity in the brain in its adolescent age (about P40).

Results: Neurodevelopmental impairment induced by mild early-life NEC was reflected by rsfMRI in adolescent rats.

Impact: We provide evidence showing that preterm NEC may induce the subsequent alteration in the functional brain network. Our results indicate the association between the early-life local intestine inflammation and long-term neurodevelopmental impairment, suggesting the interaction of the gut-brain axis.

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