Abstract #2559

Altered Gyrification in Fetal Growth Restriction with Prenatal Magnetic Resonance Images

Bossmat Yehuda^1,2, Aviad Rabinowich, MD^1,3,4, Daphna Link-Sourani¹, Netanell avisdris¹, Ori Ben-Zvi¹, Bella Spector-Fadida¹, Leo Joskowicz⁵, Liat Ben-Sira, MD^2,3,4, Elka Miller, MD⁶, and Dafna Ben Bashat^1,2,3

¹Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ³Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁴Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁵School of Computer Science and Engineering, The Hebrew University of Jerusalem, Israel, Jerusalem, Israel, ⁶Children's Hospital of Eastern Ontario (CHEO), Department of Medical Imaging, University of Ottawa, Ottawa, ON, Canada

Synopsis

Keywords: Prenatal, Fetus, gyrification, fetal growth restriction

Motivation: Fetal growth restriction (FGR) is highly associated with adverse outcomes. While reduced brain volume is associated with FGR, knowledge regarding cortical developmental is scarce.

Goal(s): We aimed to quantitatively assess differences in brain volumes and cortical folding patterns between FGR and appropriate-for gestational-age (AGA) fetuses, and between FGR with normal and abnormal pulsatile-index (PI) measured by Doppler-US in the middle-cerebral-artery (MCA).

Approach: Gyrification and brain volume were computed using an automatic method based on T₂-weighted MRI.

Results: Significant reduction of brain volume and gyrification were detected in FGR compared with AGA, and in gyrification in fetuses with abnormal MCA-PI.

Impact: Reduced gyrification in FGR fetuses can offer insights into the pathomechanism linking abnormal MCA-PI, cortical development, and postnatal outcomes. This may enable marker for assessing the severity of restriction and facilitate pregnancy management by determining the optimal time for delivery.

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