Abstract #2573

Time-dependent diffusion MRI-based microstructural mapping of cervical cancer: correlation with immunohistochemical biomarkers

Weijian Wang¹, Yimeng Kang¹, Wenjing Li¹, Shujian Li¹, Wenhua Zhang¹, Kun Zhang¹, Liangjie Lin², Zhigang Wu², Peng Sun², Yong Zhang³, and Jingliang Cheng¹

¹MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Zhengzhou, China, ²Advanced Technical Support, Philips Healthcare, Beijing, China, ³the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Synopsis

Keywords: Microstructure, Diffusion/other diffusion imaging techniques, cervical cancer, immunohistochemistry, time-dependent diffusion MRI, microstructural mapping, oscillating gradient spin-echo

Motivation: Some immunohistochemical (IHC) markers are gradually accepted as vital prognostic factors guiding therapy in cervical cancer (CC).

Goal(s): This study aimed to evaluate the relationship of time-dependent diffusion MRI (t_d-dMRI)-based microstructural mapping and IHC status of CC.

Approach: Quantitative information on cell microstructure are obtained by fitting the IMPULSED model to the t_d-dMRI data.

Results: Intracellular fraction (f_in) and cellularity were significantly correlated with the PD-L1 expression, respectively. In addition, f_in and cellularity were significantly correlated with Ki-67. The results suggested that microstructural mapping might facilitate the establishment of novel diffusion-derived biomarkers to estimate IHC status and orient treatment of CC.

Impact: The td-dMRI-based microstructural mapping showed the potential to estimate the IHC status of cervical cancer for the first time.

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