Keywords: Susceptibility/QSM, Quantitative Susceptibility mapping, functional Quantitative Susceptibility Mapping
Motivation: fQSM quantitative and spatially-specific information on brain activity may be valuable in studying cortical substructures. However, fQSM response to varying stimulus intensity is unknown, and, as for QSM, reduced z-coverage may affect quantification.
Goal(s): We aimed to assess fQSM linearity to stimulus intensity and its dependence on z-coverage.
Approach: We employed visual stimuli with different contrasts and acquired whole-brain fQSM datasets that were truncated to simulate partial coverage.
Results: We reported fQSM response linearity to different contrasts and, while extremely small coverage led to brain activity underestimation, whole-brain acquisitions were not necessary to obtain accurate results.
Impact: Linearity and feasibility at reduced z-coverage, together with high spatial specificity, suggest that fQSM may provide added value to the functional study of cortical substructures.
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