Keywords: Susceptibility/QSM, Quantitative Susceptibility mapping, Susceptibility separation, Repeatability, Reproducibility, 3T, scan-rescan
Motivation: Susceptibility separation methods aim to separate co-existing myelin and iron contributions. However, their repeatability has not been investigated.
Goal(s): Evaluating repeatability of existing separation methods in brain and comparing their performance.
Approach: Three methods (χ-Sep, χ-SepNet, and APART) were applied to 3T scan-rescan data of 21 healthy subjects, and the resultant dia- and paramagnetic maps were evaluated in white and deep gray matter regions.
Results: Reliability varied by method and region, with many regions showing moderate to good reliability. Average repeatability coefficients were 4 ppb and 8 ppb in white matter and iron-rich deep gray regions, respectively.
Impact: Susceptibility separation methods showed moderate to good reliability in most brain regions, and sub-voxel changes around 5 ppb might be error. Comparing values reported using different methods might not be straightforward, as the difference between measurements could exceed 15 ppb.
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