Keywords: Alzheimer's Disease, Alzheimer's Disease, Cognition
Motivation: Glymphatic function, which eliminates soluble proteins from the brain, is positively associated with cognitive function for patients with Alzheimer’s disease (AD).
Goal(s): To analyze whether the associations between glymphatic function and cognitive function were mediated by regional cortical thickness (CTh) for patients with AD.
Approach: Mediator analysis was conducted to explore the ALPS index as a predictor, regional CThs as mediators, and cognitive test scores as outcomes.
Results: Mediation analysis showed that regional CTh was a significant mediator between ALPS index and executive function.
Impact: CTh is a key mediator between impaired glymphatic function and cognitive decline. Our findings provide insights regarding associations between decreased glymphatic function and cognitive decline in patients with AD.
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