Abstract #2629

Association of Cognitive Reserve and Glymphatic Function in Mild Cognitive Impairment Patients Using DTI-ALPS

Liang Zhou^1,2, Wenxia Yang^1,2, Yang Liu^1,2, Jiaceng Li^1,2, Kai Ai³, Peng Wu⁴, and Jing Zhang^2,5

¹Second Clinical School, Lanzhou University, Lanzhou, China, ²Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, ³Philips Healthcare, Xi'an, China, ⁴Philips Healthcare, Shanghai, China, ⁵Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou University Second Hospital, Lanzhou, China

Synopsis

Keywords: Dementia, Diffusion Tensor Imaging

Motivation: Cognitive reserve (CR) could moderate the cognitive decline. But the association between the glymphatic function and CR in mild cognitive impairment (MCI) remains unclear.

Goal(s): To evaluate the association between CR and glymphatic function.

Approach: By using diffusion tensor imaging along the perivascular space (DTI-ALPS) to acquire an index (ALPS-index) in MCI and normal controls (NCs). The education level was used as a representation of CR. We used mediator analysis to explore the association among ALPS-index, CR and cognitive function.

Results: MCI exhibited decreased glymphatic activity than NCs and CR mediates the link between the glymphatic system and cognition.

Impact: MCI patients exhibited decreased glymphatic activity compared to NCs. Our study confirms the protective effect of CR in MCI patients, and this protective effect can against the cognitive impairment by improving CR.

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