Keywords: Epilepsy, Diffusion/other diffusion imaging techniques
Motivation: Self-limited epilepsy with centrotemporal spikes (SLECTS) is the most prevalent type of idiopathic childhood epilepsy. However, the underlying pathophysiologic mechanisms of SLECTS is largely unknown.
Goal(s): Studies on the glymphatic system function in SLECTS patients may contribute to better understanding of the associated mechanisms.
Approach: Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) was used to evaluate the glymphatic system function.
Results: The SLECTS patients exhibited altered DTI-ALPS index. Altered DTI-ALPS index were more severe in ipsilateral than in the contralateral hemisphere. Moreover, RSLECTS (Right SLECTS ) and LSLECTS (Left SLECTS) patients exhibited different change patterns of the glymphatic system.
Impact: This study indicating that the glymphatic system may be a separate system in the left and right hemispheres. Patients with RSLECTS and LSLECTS exhibited different pattern of glymphatic system changes. Our research may contribute to elucidating the pathophysiologic of SLECTS.
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