Abstract #2636
Validation of diffusivity analysis along the perivascular space (ALPS) index as a biomarker for vascular cognitive impairment and dementia
Xiaodan Liu1,2, Giuseppe Barisano3, Pauline Maillard4, Arvind Caprihan5, Steven Cen6, Xingfeng Shao1, Kay Jann1, John Ringman6, Hanzhang Lu7, Konstantinos Arfanakis8,9, Charles DeCarli10, Brian T. Gold11, Clandia L. Satizabal12, Mohamad Habes13, Lara Stables14, Herpreet Singh15, Bruce Fischl16,17,18, Andre van der Kouwe16,17,18, Kristin Schwab15, Karl G. Helmer16,17,18, Steven M. Greenberg15, and Danny JJ Wang1,6
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 2Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 3Neurosurgery, Stanford University, Stanford, CA, United States, 4Department of Neurology, University of California, Davis, Davis, CA, United States, 5The Mind Research Network, Albuquerque, NM, United States, 6Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 7Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 8Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 9Diagnostic Radiology and Nuclear Medicine, Rush University, Chicago, IL, United States, 10University of California, Davis, Davis, CA, United States, 11Neuroscience, University of Kentucky, Lexington, KY, United States, 12Population Health Sciences and Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 13Neuroimage Analytics Laboratory and Glenn Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 14Neurology, University of California, San Francisco, San Francisco, CA, United States, 15Neurology, Massachusetts General Hospital, Boston, MA, United States, 16Radiology, Harvard Medical School, Boston, MA, United States, 17Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 18Computer Science and AI Lab, Massachusetts Institute of Technology, Cambridge, MA, United States
Synopsis
Keywords: Neurofluids, Diffusion Tensor Imaging, glymphatic system, cerebral small vessel disease (cSVD), vascular cognitive impairment and dementia (VCID))
Motivation: To test the validity of the ALPS index as a biomarker for VCID
Goal(s): To test our hypothesis that ALPS index is an independent biomarker for the cognitive decline in cSVD.
Approach: Participants from MarkVCID consortium underwent baseline and follow-up MRI examinations and clinical evaluations of cognitive function
Results: We found the baseline ALPS index was correlated with the existing biomarkers of cSVD and VCID, and was independently associated with the baseline cognitive performance
Impact: Our study provides the clinical validation of the ALPS index as a sensitive and independent biomarker for the cognitive function of cSVD related VCID.
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