Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound
Motivation: The effectiveness of low-intensity focused ultrasound (LIFU) for neuromodulation may be compromised by inaccuracies in target localization and variable energy deposition caused by skull characteristics.
Goal(s): We aimed to improve the estimation of LIFU pressure using MR-acoustic radiation force imaging (ARFI) and test whether the adjusted LIFU intensity correlates with treatment outcomes in a behavioral economic task using sucrose pellets.
Approach: Eight female rats underwent LIFU targeting the nucleus accumbens (NAc) bilaterally with three different pressures. MR-ARFI confirmed the targeting and corrected the intensities during LIFU treatments.
Results: Improved correlations between behavioral outcomes and ARFI-adjusted LIFU intensity were observed.
Impact: Our preliminary findings demonstrate the beneficial effects for using MRI-ARFI not only to verify the FUS target location but also to refine LIFU intensities in neuromodulation procedures.
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