Abstract #2757

Virtual elastography based on an intravoxel incoherent motion for assessing chronic kidney disease

Yueyao Chen¹, Ruirui Qi¹, Wenxi Liu², Qiumei Liang¹, Peiyin Luo¹, Junfeng Li¹, Qiuyi Chen¹, Jingtong Pan¹, Feifei Qu³, Haodong Qin⁴, Yanglei Wu⁵, Fanqi Meng¹, and Hanqing Lyu¹

¹Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital (The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine), Shenzhen, China, ²Shenzhen University, Shenzhen, China, ³MR Research Collaboration, Siemens Healthineers, Shanghai, China, ⁴MR Research Collaboration, Siemens Healthineers, Guangzhou, China, ⁵MR Research Collaboration, Siemens Healthineers, Beijing, China

Synopsis

Keywords: Kidney, Data Analysis, Aging, chronic kidney disease, diagnosis,renal stiffness, intravoxel incoherent motion, shifted apparent diffusion coefficients ,virtual elastography

Motivation: Various b values of shifted apparent diffusion coefficients (sADC) and virtual magnetic resonance elastography (vMRE) were not validated for renal stiffness. Hence, a new method was required for assessing chronic kidney disease (CKD) noninvasively.

Goal(s): To investigate the relationship between sADC and vMRE and the clinical indicators and diagnostic efficacy of CKD.

Approach: The μ_diff generated with sADC was used to quantify renal stiffness. The data were analyzed using Spearman, partial correlation, Mann–Whitney U test, and receiver-operating characteristic curves.

Results: sADC and vMRE were effective in assessing renal function and diagnosing CKD, but distinctly at various b values.

Impact: This study provides a reference b value for sADC and vMRE and suggests that vMRE could be used as a new noninvasive technique to assess chronic kidney disease.

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