Keywords: Vessels, Heart, NMR spectroscopy
Motivation: Heart valve disease (HVD) is a complex condition with a poorly known pathogenesis.
Goal(s): NMR-based serum metabolomics of HVD patients (aortic, mitral valve, and double valve replacement) and healthy controls to identify potential biomarkers for HVD.
Approach: Proton NMR spectroscopy
Results: The results obtained from PLS-DA and VIP score plots of metabolites in serum showed a separation between patients with HVD and HC.
Impact: To understanding the potential metabolic alteration such as BCAA, and fatty acids, amino acids, and carbohydrate metabolism associated with inflammation, oxidative stress, and tissue degradation of HVD.
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