Keywords: Low-Field MRI, Low-Field MRI
Motivation: Ultra-low field scanners can vastly improve access to neuroimaging, and implementing MRI techniques to quantify microstructure allows monitoring of both neurodegenerative diseases as well as myelination trajectories during development.
Goal(s): To assess the reliability of microstructure-sensitive methods at ultra-low field before large-scale deployment.
Approach: The reliability of recently developed magnetization transfer (MT) imaging and T2 mapping sequences at 64mT was assessed in 5 healthy subjects through histograms, difference maps and correlation analysis in white matter.
Results: Both MT ratios and T2 values were highly reproducible in the test cohort.
Impact: Techniques to measure microstructure, even semi-quantitatively, can be useful for tracking myelination/demyelination. Here we demonstrate the reproducibility of two such methods: magnetization transfer imaging and T2 mapping, in a small cohort of healthy adults at ultra-low field (64mT).
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