Keywords: Low-Field MRI, Brain, Small vessel disease
Motivation: Field-cycling MRI makes it possible to characterise the clinical potential of endogenous spin-lattice R1 image contrast that arises at ultra-low-magnetic field strengths.
Goal(s): Our goal was to examine the extent translated motion correction and denoising approaches improve the utility of R1 mapping performed at ultra-low field.
Approach: : Improvements in sensitivity to differences in R1 between tissue types and fitting accuracy were determined across brain and head tissues.
Results: Improvements in sensitivity and goodness of fit were observed. Significant difference in R1 values between regions of white matter and confluent small vessel disease were observed between 0.2 - 200 mT.
Impact: The improvement in sensitivity of R1 mapping using translated motion correction and denoising approaches provides new opportunities to assess the clinical potential of new endogenous image contrast mechanism at ultra-low field strengths.
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