Abstract #2865

Feasibility of high b value in vivo cardiac diffusion in humans with ultra-high gradient strength scanner

Thomas Garrett¹, Danielle Kara¹, Shi Chen¹, Yuchi Liu², Xiaoming Bi³, and Christopher Nguyen^1,4,5,6

¹Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ²Siemens Medical Solutions USA, Inc., Cleveland, OH, United States, ³Siemens Medical Solutions USA, Inc, Los Angeles, CA, United States, ⁴Cardiovascular Medicine, Heart Vascular Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ⁵Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁶Department of Biomedical Engineering, Case Western Reserve University & Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: DWI/DTI/DKI, Diffusion Tensor Imaging

Motivation: New technology allows for higher gradient strengths and therefore higher b-values to be used in cardiac diffusion tensor imaging (cDTI).

Goal(s): To compare cDTI parameter maps for the current standard and increased b-values both qualitatively and quantitatively.

Approach: Two cDTI datasets with b=500 s/mm² and b=1000s/mm²were acquired from nine healthy subjects. The resulting DTI parameter maps were compared through visual analysis and a series of paired t-tests.

Results: Both qualitative and quantitative data between parameter maps show improved detail and higher precision in high b-value data compared to standard b-value data.

Impact: A new ultra-high-performance 3T MR system allows for higher diffusion gradients and b-values. Our study shows high b-values (b=1000 s/mm²) lead to higher levels of detail and precision in cardiac DTI of healthy subjects compared to standard b-values (b=500 s/mm²).

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