Abstract #2897

Feasibility of quantitative water T2 mapping for detection of renal tubulointerstitial changes in radiation nephropathy

Julia Stabinska^1,2, Joe Piccolo², Anupriya Chhabra², Zhi Li², Kathy Gabrielson³, Zinia Mohanta^1,2, Ioanna Liatsou², Farzad Sedaghat², Robert F. Hobbs², George Sgouros², and Michael T. McMahon^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Kidney, Kidney

Motivation: As the current diagnostic tools are insensitive to early kidney damage in radiation nephropathy, there is a clinical need for improved biomarkers that can be used to noninvasively assess tubulointerstitial changes in RN.

Goal(s): To verify whether MRI-based T2 mapping can detect microstructural changes in renal parenchyma resulting from radiation-induced kidney damage.

Approach: We performed T2 mapping in two mouse models of radiation nephropathy, one involving external beam irradiation and the other utilizing internal irradiation with α-particle-emitting actinium (²²⁵Ac) radiolabeled antibody.

Results: Increased T2 values were found in the cortex and outer medulla of the treated mice compared to the healthy controls.

Impact: MRI-based T2 values could serve as a quantitative biomarker for detecting microstructural changes specific to EBRT and αRPT.

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