Abstract #2923

Brain Cortical Changes in Pediatric and Adolescent Patients with Intermittent Exotropia Basic Type: SBM Analysis on MRI Morphological Data

Xin-zhi Zhao^1,2, Qing-lei Shi^1,3, Wan Yi Chen⁴, Yi Fang⁵, Huixin Li⁶, Jie Mao⁴, Ren-zhi Wang¹, Zhaohui Liu⁷, and Xiang Wan³

¹School of Medicine, Chinese University of Hong Kong(Shenzhen), Shenzhen, China, ²Siemens Healthineers (China), Shanghai, China, ³Shenzhen Research Institute of Big Data, Shenzhen, China, ⁴School of data science, Chinese University of Hong Kong(Shenzhen), Shenzhen, China, ⁵Department of Neurosurgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ⁶Department of Ophthalmology, Beijing Tongren Hospital, Beijing, China, ⁷Department of Radiology, Beijing Tongren Hospital, Beijing, China

Synopsis

Keywords: Gray Matter, Head & Neck/ENT, strabismus, ophthalmology, SBM

Motivation: Basic type of intermittent exotropia (IXT) is one of the most common strabismus subtypes in children and adolescents, yet a clear consensus of its etiology and treatment approach is still lacking.

Goal(s): To discover abnormal brain cortical structures related to this disease and explore the central nervous system mechanisms of IXT.

Approach: Basic type IXT patients and healthy volunteers were recruited, cortical structures extracted from their whole-brain MRI morphological data were compared using the SBM method.

Results: Distinct differences of cortical thickness and curvature between the two groups were found, located in the right rostral middle frontal cortex and the left precuneus.

Impact: Our results suggesting that the primary pathological changes in this disease may differ from traditional perspectives. Based on these findings, we have proposed a new pathogenic hypothesis and introduced novel treatment recommendations.

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