Keywords: Gray Matter, Dementia
Motivation: To reveal the underlying neuroimaging pathology mechanisms of cognitive impairment in patients with delayed neurologic sequelae (DNS) following carbon monoxide (CO) poisoning.
Goal(s): To investigate the relationship among white matter hyperintensities (WMH), gray matter (GM) volume and cortical thickness alteration, and cognitive impairment severities in patients with DNS following CO poisoning.
Approach: Clinical retrospective observational study
Results: The DNS patients with dementia (DNS-D) group showed more severe GM atrophy and higher WMH load than those with mild cognitive impairment (DNS-MCI) group. Reduced GM volume in 16 subregions of the bilateral prefrontal, left occipital, bilateral temporal, and cerebellar regions mediated the WMH-induced cognitive decline.
Impact: Using the neuroimaging methods to explore the pathophysiological mechanism of DNS with cognitive impairment could provide a theoretical basis for exploring new therapeutic approaches. Our results provide preliminary evidence that the role of regional GM atrophy in WMH-induced cognitive decline.
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