Keywords: Gray Matter, Cancer, Neoadjuvant chemotherapy, Breast cancer, Chemotherapy-related cognitive impairment
Motivation: Chemotherapy-related cognitive impairments (CRCIs) are common in patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). However, the mechanisms of CRCI are still unclear. Excess brain iron accumulation might be a potential mechanism for cognitive impairment.
Goal(s): Evaluating the longitudinal changes in brain iron content in participants with breast cancer after NAC using quantitative susceptibility mapping (QSM)
Approach: 53 women with breast cancer were enrolled, and each was imaged with T1WI and QSM and performed before and after NAC.
Results: Brain iron content derived from QSM changed in participants with breast cancer after NAC, and was related to cognitive performance.
Impact: Iron content changes derived from QSM may providing a new objective basis for the mechanism of CRCI.
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