Abstract #2936

Towards precise quantification of chronic active MS lesions using submillimeter isotropic QSM with 3D-EPI at 3T

Sreekanth Madhusoodhanan Nair¹, Arzu Has Silemek^1,2, Brian Renner¹, Elaina Gombos¹, Bryan Quah¹, Mustafa Subhi¹, Jin Jin³, Fei Han⁴, Nader Binesh⁵, Marcel Maya⁵, Debiao Li², Marwa Kaisey¹, Nancy L Sicotte¹, Omar Al-Louzi¹, and Pascal Sati^1,2

¹Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³Siemens Healthcare Pty Ltd, Brisbane, Australia, ⁴Siemens Medical Solutions, Los Angeles, CA, United States, ⁵Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: Quantitative susceptibility mapping (QSM) enables in vivo detection of chronic active brain lesions in Multiple Sclerosis (MS) due the presence of iron-laden lesion borders also called Paramagnetic Rim Lesions (PRL).

Goal(s): To evaluate the feasibility of generating submillimeter isotropic resolution QSM using 3D-EPI for precise quantification of PRL in MS patients.

Approach: Separate masks for the lesion rim and lesion core were generated.

Results: Submillimeter resolution reduces the partial volume averaging effect and enables measurement of the lesion rim in PRL⁺ lesions, which exhibit susceptibility values 3 times that of the lesion core.

Impact: This study demonstrates the feasibility of submillimeter isotropic quantitative susceptibility mapping to precisely quantify the magnetic susceptibility properties of MS lesions.

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