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Abstract #2944

Serum 24-Hydroxycholesterol is weakly correlated with brain water content, myelin water fraction and T1 relaxation in different stages of MS

Noah Marini1,2, Pierre Becquart3, Roger A Dyer4, Anthony Traboulsee5,6, Robert L Carruthers5, Shannon H Kolind1,2,5,6,7, Alice J Schabas5, Ana-Luiza Sayao5, Virginia Devonshire5, Roger Tam1,8, Wayne Moore2,3,5, David KB Li1,5,6, Jacqueline A Quandt2,3,5, Irene M Vavasour1,2, and Cornelia Laule1,2,3,5
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 3Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 4Analytical Core for Metabolomics and Nutrition, BC Children's Hospital Research Institute, Vancouver, BC, Canada, 5Medicine, University of British Columbia, Vancouver, BC, Canada, 6MSMRI Research Group, University of British Columbia, Vancouver, BC, Canada, 7Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 8School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, serum, white matter, myelin, water content, T1, brain

Motivation: Quantitative and specific MRI methods may better characterize brain changes in multiple sclerosis (MS). Serum biomarkers that reflect advanced MRI measures would be an accessible and cost-effective tool for tracking these changes.

Goal(s): To explore the ability of serum 24-hydroxycholesterol to reflect changes in advanced brain MRI measures in MS.

Approach: 103 MS participants with diverse disease course subtypes underwent 3T MRI and same-day venous blood sampling.

Results: Lesion water content and myelin water fraction (MWF), normal appearing white matter MWF and T1, and diffusely abnormal white matter MWF demonstrated relationships with serum 24-hydroxycholesterol in specific disease courses of MS.

Impact: Correlation between serum 24-hydroxycholesterol and advanced MRI measures in different MS subtypes encourage further investigation of its use as a supportive marker. The development of MRI and serum markers could improve the sensitivity and frequency of monitoring MS disease progression.

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Abstract

Keywords