Abstract #2946

Resolution of glial activation in relapsing and primary progressive MS over 2 years with ocrelizumab: longitudinal MR spectroscopy study

Bretta Russell-Schulz¹, Erin L MacMillan^2,3, Glaynel Alejo², Irene M Vavasour², Christopher Harp⁴, Briana Cameron⁴, Ryan Winger⁴, Sherman Jia⁴, Ann Herman⁴, Helen Cross⁵, Roger Tam^1,6, Anthony L Traboulsee^1,5, Robert Carruthers⁵, and Shannon H Kolind^1,2,5,7

¹MS MRI Research, University of British Columbia, Vancouver, BC, Canada, ²UBC MRI Research, University of British Columbia, Vancouver, BC, Canada, ³Philips Canada, Mississauga, ON, Canada, ⁴Genentech Inc., A Member of the Roche Group, South San Francisco, CA, United States, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶School for Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ⁷Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Multiple Sclerosis, Spectroscopy

Motivation: Need for treatment tracking biomarkers in multiple sclerosis (MS).

Goal(s): To demonstrate increased sensitivity to metabolite changes in a more homogeneous MRS voxel in RMS and to investigate whether PMS exhibits a similar trend with treatment.

Approach: Single voxel spectroscopy to examine metabolite changes in a large white matter region over time in ocrelizumab treated MS patients compared to single timepoint healthy controls.

Results: Marker of glial cell density and activation decreased over 2 years of treatment in both relapsing (similar to previously study) and progressive MS. A weak correlation was observed between the glial marker and measure of disability at baseline.

Impact: Magnetic resonance spectroscopy (MRS) offers biomarkers of glial density/activation that may solve a clinical unmet need to track the neuroinflammatory response to multiple sclerosis (MS) therapies. This study demonstrates how MRS biomarkers change with treatment in MS white matter.

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