Abstract #2948

Imaging the brain with multiple sclerosis using 3D CUBE CEST MRI at clinical 3T

Jianpan Huang¹, Yingying Lin¹, Peng Cao¹, Chia-Wei Lee², Ziyan Wang¹, Pei Cai¹, Chi Yan Lee³, Kyongtae Ty Bae¹, Henry KF Mak¹, Kannie WY Chan^4,5,6, and Koon Ho Chan³

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, ²Research Group, GE Healthcare, Taipei, Taiwan, ³Department of Medicine, The University of Hong Kong, Hong Kong, China, ⁴Department of Biomedical Engineering, The University of Hong Kong, Hong Kong, China, ⁵Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, China

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: CEST MRI is a molecular imaging technique that has potential to image the changes of lipids and proteins during demyelination in human brain with multiple sclerosis (MS).

Goal(s): We aimed to explored the sensitivity of different CEST contrasts in differentiating MS brain from healthy control (HC) brain at 3T.

Approach: CEST MRI based on a 3D CUBE acquisition module was applied to image the brain of MS patients and HC subjects at a clinical 3T scanner.

Results: CEST MRI could sensitively identify MS from HC. Amide CEST, rNOE and MT showed significantly lower signals in the MS brain compared to HC brain.

Impact: This study demonstrated the alterations in CEST contrasts in the human brain with multiple sclerosis using a clinical 3T MRI. It provides valuable insights for the clinical application of CEST MRI in diagnosing multiple sclerosis.

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