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Abstract #2949

Study of Neurometabolic Alterations in Multiple Sclerosis Using Fast High-Resolution 3D 1H-MRSI

Bin Bo1, Tianyang Sheng2, Weijun Tang3, Yibo Zhao4,5, Yudu Li4,6, Wen Jin4,5, Rong Guo4,7, Xiangjun Chen2, Zhi-Pei Liang4,5, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China, 3Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China, 4Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 6National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 7Siemens Medical Solutions USA, Inc., Urbana, IL, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis

Motivation: Multiple sclerosis (MS) is characterized by diverse metabolic alterations. 1H-MRSI provides a unique capability for non-invasive mapping of neurometabolites but is often limited in resolution, scanning time, and brain coverage.

Goal(s): Our goal was to demonstrate the feasibility of high-resolution whole-brain 1H-MRSI for characterizing metabolic alterations in MS.

Approach: 3D 1H-MRSI scanning using SPICE technology (scan time: 10 minutes, resolution: 2×3×3 mm3, FOV: 240×240×120 mm3) was performed on 44 MS patients.

Results: N-acetylaspartate (NAA), myo-inositol (mI), creatine, and choline levels altered among different lesion types and peri-plaque regions. NAA and mI/NAA differentiated RRMS and PMS patients in association with clinical scores.

Impact: High-resolution whole-brain 1H-MRSI provides a promising tool for non-invasive metabolic imaging to characterize MS pathophysiology.

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Abstract

Keywords