Abstract #3000

Evaluate the effects of software on repeatability and reproducibility in brain volume measurements

Ruifeng Dong¹, Amritha Nayak^1,2,3, and Carlo Pierpaoli¹

¹Laboratory on Quantitative Medical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States, ²Henry Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, United States, ³2) The Military Traumatic Brain Injury Initiative (MTBI2), Uniformed Services University of the Health Sciences, Bethesda, MD, United States

Synopsis

Keywords: Segmentation, Segmentation

Motivation: MRI-based brain volumetry is a valuable tool to assess human brain development and brain disorders. However, insuring repeatability and reproducibility is essential for a larger dissemination.

Goal(s): Our goal was to compare the repeatability/reproducibility in volume measurements by different popular software tools.

Approach: We performed T2w scans and repeated T1w scans for 82 subjects on two 3T scanners. We computed the volume within- and between-scanner variabilities.

Results: Improved masking helps reduce variability in Freesurfer’s volume measurements. Synthseg and vol2Brain give better volume repeatability/reproducibility compared to Freesurfer.

Impact: Our results provide quantification of the effects on repeatability/reproducibility from different software enabling clinicians and researchers to make an informed choice for data processing.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.