Keywords: Hyperpolarized MR (Non-Gas), Metabolism, carbon-13 imaging, x-nuclei MRI, metabolic imaging, flexible RF coil, CSI
Motivation: For hyperpolarized 13C metabolic imaging studies, a challenge is to achieve high temporal resolution without decreasing spatial and/or spectral resolution.
Goal(s): To accelerate hyperpolarized 13C MRI by combining a 2D Chemical Shift Imaging (CSI) sequence with SENSitivity Encoding (SENSE) reconstruction.
Approach: Due to the low natural abundance of 13C, the sensitivity maps needed for SENSE reconstruction cannot be pre-acquired. As such, in this work, the novel approach of using sodium sensitivity maps was demonstrated.
Results: SENSE reconstruction corrected aliased images, where in-vivo metabolic information was acquired with a 4-fold temporal acceleration.
Impact: As hyperpolarized 13C metabolic imaging is clinically translated, there is a need for easy-to-implement, fast, and robust imaging techniques. Therefore, this study implemented a novel 13C technique to accelerate Chemical Shift Imaging: a ubiquitous and robust sequence.
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