Abstract #3052

Towards cardiac DMI at clinical field strengths

Jie Xiang¹, Robin de Graaf², Henk De Feyter², Monique Thomas², Lauren Baldassarre³, Jennifer Kwan³, Daniel Coman², Peter Herman², and Dana Peters²

¹Yale University, New Haven, CT, United States, ²Yale University School of Medicine, New Haven, CT, United States, ³Cardiovascular Medicine, Yale School of Medicine, New Haven, CT, United States

Synopsis

Keywords: Deuterium, Metabolism

Motivation: Deuterium metabolic imaging (DMI) might permit mapping of cardiac metabolism by MRI.

Goal(s): To port DMI tools developed at 11.7T for mice to 3T, and develop methods for cardiac DMI.

Approach: Simulations, phantoms, and in vivo studies were conducted to measure SNR at 3T, develop an optimized protocol, and account for B0 inhomogeneity.

Results: At 11.7T, cardiac DMI was tested in a control mouse. At 3T, phantom studies showed that multi-echo bSSFP methods yield increased SNR vs. GRE. B0-mapping helps in isolating the metabolites in phantoms.

Impact: Development of DMI tools for use in cardiac DMI at clinical field strengths.

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